Searching for Dragon Bones

Recently our Book-Reading Group in Schio (Italy) decided to read Tracy Chevalier's book "Remarkable Creatures". It is the story of 2 women in early 19th century England and their love for fossils and old bones.

Reading this book reminded me of a visit to a museum in Bologna some years ago, as well as, of discussions about dinosaur bones in the Gobi desert in Mongolia. Friends had told me that in Mongolia and China, people used to believe that the dinosaur bones were dragon-bones, and were used as medicines by traditional healers.

This post is about Tracy Chevalier's book, as well as about discovery of fossils in medieval Bologna. It is a kind of a rambling post about how scientific discoveries are inter-connected and can change the way we see the world around us. Let me start with Chevalier's book.

Remarkable Creatures

Chevalier is a British author of American origins who writes historical novels. She became famous with her book "The girl with the pearl earring" in 1999 while "Remarkable Creatures" came out in 2009.

The book is set in the coastal town of Lyme Regis in south England. The tiny town of Lyme has been the backdrop of many books, including "Persuasion" by Jane Austen and "French Lieutenant's Woman" by John Fowles. It is a fiction-book based on real persons, who lived there in the 19th century. On her website, Chevalier provides the following background to her decision to write this book:

A few years ago I went with my son to a small dinosaur museum in Dorchester, on the south coast of England. Among the usual displays, there was a wall devoted to Mary Anning, who lived in the early 19th century in the nearby town of Lyme Regis, where fossils are abundant. The display showed a sketch of Mary on the beach, holding a hammer and wearing a top hat to protect her from falling rocks. At age 12 she discovered the first complete specimen of an ichthyosaur, a marine reptile about 200 million years old

The book starts with the friendship between the two women - the 12 years old Mary Anning from a working class family and a resigned-to-spinsterhood, Elisabeth Philpot. Mary searches for the fossils on the coast to sell them to the tourists. Elisabeth has been sent to live in Lyme, as her brother has decided to get married and his wife does not wish to share the house with his sisters. In Lyme, Elisabeth discovers her love for the fossils and old bones, and in the process, recognises the genius of Mary in finding them.

A dinosaur skeleton, now displayed in the Natural History museum in London, discovered by Mary Anning, plays a key role in the story. I love that museum and have been there a few times (2 of the images used in this post are from that museum). However, before reading this book, I had no idea about Mary Anning and the role she had played in discoveries of the dinosaur skeletons in England.

Book's Themes

The story is set in the early 19th century England, a period when class distinctions were still strong and the society did not accept friendships between persons of different classes. It was also a period when women were much lower in the hierarchy compared to the men - they did not have any independent rights and were dependent upon the men of their families for all decisions. It was a period when religious orthodoxy dominated and was hard to challenge.

It was a period of transition, where the finding of fossils was problematic as it raised issues for which the answers inevitably led to a questioning of religious dogmas. The Bible said that God had made the creation over a period of 6 days and all creatures made by God were perfect. The fossils and dinosaurs did not fit into this narrative because they implied that some creatures had existed in the past and had become extinct. The church negated these suppositions which did not fit the theory of creationism.

In that period, only men were supposed to be discoverers and scientists while women like Mary or Elisabeth were not supposed to be one. Thus, men interested in the fossils and old bones of giant animals (the word dinosaur had not yet been coined), took the knowledge and specimens from Mary and showed them off as their own finds. The book concludes as the first fissures apear in this male-dominated construction of the scientific world and Mary becomes known as the person who understands fossils much better than anyone else.

It is a gentle book, focusing on the social milieu as well as, on the inner lives of its female protagonists, and is very easy to read. There are parts of the story, like the man who had duped Mary suddenly discovers his noble side, which are a little unconvincing but overall the book is informative and enjoyable. Even Jane Austen makes a fleeting appearance in the story. For me, the most interesting parts of this book are those where the process of finding the fossils and the beginning of slow understanding about their origins are described.

Aldrovandi & Geology

Reading about fossils reminded me of a naturalist from medieval Bologna in Italy. In a recent article by Lawrence Wright in the New Yorker, Bologna is described as "the giant churches, the red-tiled roofs, the marble walkways under arched porticoes; a stately city, low-slung, amber hued, full of students and indomitable old couples. During the Middle Ages, Bologna was home to more than a hundred towers, the skyscrapers of their era, which served as show-places of wealth and ambition for powerful oligarchs. Two of the remaining ones have become symbols of Bologna: one slightly out of plumb, the other as cockeyed as its cousin in Pisa."

This article touches on the social transformations brought about by the pandemic of black death (plague) in the 14th century and proposes that the pandemic had led to the period of Italian Renaissance and to a new way of understanding the world. It asks what kind of the transformations will be stimulated by the present Covid-19 pandemic and in which ways those will shape our future world.

One of the key figures of 16th century Bologna who had contributed to the scientific transformation of Renaissance was the naturalist Ulisse Aldrovandi. He was born in Bologna in 1522. Leonardo da Vinci had died a couple of years earlier while Michelangelo had yet to start painting the Sistine chapel. Thus, we were in the middle of Italian Renaissance period. It was also the time when the Spanish inquisition had already started and it was easy to be accused of being a heretic. In fact, Aldrovandi himself was imprisoned for about a year and a couple of decades after his death, in 1633 Galileo was sentenced to life-imprisonment for suggesting that the earth was not the centre of the universe and it revolved around the sun.

Aldrovandi had suggested that nature had to be looked at as "juxta propria principia", that is without religious or metaphysical conditioning. Among the objects collected by Aldrovandi were some seashells found in the mountain expeditions. This raised questions in his mind about how those sea creatures had reached the mountains? The Biblical justification to these findings was in the story of universal floods and Noah's ark. These made him think critically about the study of different layers of earth and how it was composed of different kinds of rocks and minerals. In his testament written in 1604, he used the word "geology" for the first time to indicate "the study of earth".

Some diaries of Leonardo da Vinci have also been found, where he had written about the finding of seashells and fish-fossils in the mountains. One of his hypothesis was that at some point in the earth's history, the mountains had been at the bottom of some sea. Thus, while Bible imposed certain beliefs regarding the creation of the world, and inquisition awaited persons who questioned those beliefs, persons already had other ideas, which contradicted Bible's idea of creationism.

Poggi museum of Bologna holds the Aldrovandi collection and includes the collection of "Diluvianum Museum" created in early 1700 by another local naturalist, Giuseppe Monti. It presented the fossils as part of the objects created by the Biblical floods (Diluvianum). The wall paintings of this room show those floods as imagined by the artists (an example in the image below).

Thus, it was not only Mary Anning and Elisabeth Philpot, but countless others including Androvandi and Monti, who had started to explore the world with new eyes and to question it, which had created the foundations which had led to Darwin's theory of evolution and forced the church to change its position on creationism. In "Strange Creatures", Elisabeth tentatively proposes that the "6 days of creation" of the Bible could have been 6 eras of creation.

Conclusions

Often, specific scientific ideas are associated with names of specific persons. For example, the theory of evolution is linked with the name of Charles Darwin. However, as this post shows, scientific advances do not come out of a vacuum, basic knowledge which contributes to them is the work of countless others who are not remembered by the history books.

So much of history and society is taken for granted. Like the discoveries of fossils, dinosaurs and the Darwin's theory of evolution - we accept all of these almost uncritically.

Art and literature can play an important role by reminding us how and in which conditions those discoveries took place and their human costs. That understanding helps us to look at the past in a more realistic way, so that we can understand better where we have reached and where we are going.

*****

#dinosaurs #tracychevalier #bookreview #remarkable_creatures

Poverty, Disease & Disability

The links between poverty, diseases and disabilities are well known. These links can work in complex ways. This post is about studies in Brazil showing how Zika virus infection in pregnant women combined with a neurotoxin in contaminated water in drought affected areas to increase the incidence of microcephaly (smalll, less developed brain cortex) in their newborn babies, leading to cognitive disabilities.

Understanding how different factors combine together to produce an effect is important since it helps us to look for specific solutions even while we work to remove systemic disparities linked with poverty.

Zika Infection in Brazil

Though Zika virus had already been identified in 2013, it suddenly burst out as an epidemic in Brazil in 2014. Over the following 2 years, the disease quickly spread to many other countries of the Americas and pacific. The disease is transmitted mainly through a mosquito (Aedes aegypti), and also by sexual contacts and blood transfusions. That same mosquito is also responsible for spread of other diseases like Dengue, Chikangunya and Yellow Fever. Initially it was thought that Zika infection did not cause any serious complications, till October 2015 when first reports of children born with microcephaly started coming among the pregnant women who had had Zika infection. Within a month, the number of children born with microcephaly had increased ten times. Many other newborn children had other neurological problems. Other complications of Zika included congenital malformations, and paralysis due to Guillain-Barre syndrome.

By early 2017, the number of new cases of Zika had started decreasing all over, even if different countries keep reporting occasional cases. For example, in 2018, Rajasthan in India had reported a Zika outbreak. Different aspects related to this infection remain unclear including the reasons which had led to its sudden and explosive growth in 2014-15.

Drought and Water Contamination in Brazil

The Zika epidemic had coincided with a period of drought in the north-east of Brazil. With lack of rains and evaporation of water, the concentration of salinity and minerals in the water-bodies had increased, creating favourable conditions for the growth of Cyanobacteria. These bacteria produce a chemical called Saxitoxin, which damages the nerve cells. Shell fish from the water-bodies in the drought areas had higher concentrations of Saxitoxin.

Zika and Saxitoxin

An article in June 2020 issue of The Scientist explains how Zika infection had combined with Saxitoxin to increase the number of newborn children having microcephaly. It says, "While the incidence of Zika was higher in other regions of Brazil, the number of children being born with microcephaly was higher in the north-east." Fortesting, researchers infected neural cell-cultures with Zika and then exposed them to low concentrations of Saxitoxin. They found that brain cells exposed to both Zika and Saxitoxin had 2.5 times more dead cells and three times higher number of Zika virus. This meant that Saxitoxin increased virus replication and worsened its impact on the brain cells. These findings were also confirmed in animal studies.

This research also underlined the links between poverty and disability. Poor persons with Zika infection were more exposed to drinking of contaminated water and thus were disproportionately hit by higher numbers of children with microcephaly and other congenital neurological defects leading to cognitive and intellectual disabilities.

Conclusions

This case-study shows that natural conditions such as droughts can change the risks of contamination. In such situations, policies such as privatisation of water resources lead to negative consequences which disproportionately affect the poor families. For example, drinking water from deep tubewells, has created similar risks by arsenic contamination of the ground water in Bangladesh and some parts of India, which also disproportionately affects the poor.

Case studies like this are important to understand the different ways in which diseases and other negative environmental conditions can combine and cause diseases and disabilities, especially among the poor.

*****

From Butchers to Surgeons

Recently I read Dr. Lindsey Fitzharris' 2017 book called "The Butchering Art". It is not a book for the faint-hearted. In this book, she describes the way surgery was done in England till late 19th century and how two discoveries - anaesthesia and antisepsis, revolutionised it. Before those discoveries, surgery was the domain of butchers.

Reading this book raised a question in my mind about surgery in ancient India. More than two thousand years ago, ancient Ayurvedic surgeons were doing different surgeries including full-thickness skin grafts and plastic surgery operations such as rhinoplasty. I have already written a blog post about it. The question in my mind was, how did ancient Indian surgeons resolve the problems of anaesthesia and prevention of bacterial infections during their surgery?

This post is about the Fitzharris' book, as well as, about ideas of anaesthesia and asepsis from the ancient Indian text of Sushrut Samhita.

The Butchering Art

Fitzharris has a vivid way of writing. She brings alive the old and forgotten world of surgery, before the discovery of anaesthesia. Her writing is so graphic, that at times it made me feel a bit queasy. Her book starts on a December day of 1846 and describes one of the first surgeries done under the effect of Ether anaesthesia at the London University College hospital. The surgeon was Robert Liston and on that day, as usual the operation room was full of spectators, who had paid a ticket to watch the show.

It was a time when surgery was reserved for desperate and life-saving situations. Surgeons operated on conscious persons, who had to be held on their place by a group of strongmen. The lucky ones lost consciousness and were thus spared the pain of their bodies being opened and their bones being sawed off. The most important quality of surgeons was their speed in finishing the operation.

In the middle of the room was a wooden table stained with the telltale signs of past butcheries. Underneath it, the floor was strewn with sawdust to soak up the blood that would shortly issue from the severed limb. On most days, the screams of those struggling under the knife mingled discordantly with everyday noises drifting in from the street below: children laughing, people chatting, carriages rumbling by. ...At six feet two, Liston was eight inches taller than the average British male. He had built his reputation on brute force and speed at a time when both were crucial to the survival of the patient. Those who came to witness an operation might miss it if they looked away even for a moment. It was said of Liston by his colleagues that when he amputated, “the gleam of his knife was followed so instantaneously by the sound of sawing as to make the two actions appear almost simultaneous.” His left arm was reportedly so strong that he could use it as a tourniquet, while he wielded the knife in his right hand. This was a feat that required immense strength and dexterity, given that patients often struggled against the fear and agony of the surgeon’s assault. Liston could remove a leg in less than thirty seconds, and in order to keep both hands free, he often clasped the bloody knife between his teeth while working.

It was also the time when people had no understanding about bacteria and infections. If the patients did not get the infection from the dirty hands, blood-soaked aprons and instruments of the surgeons working in crowded halls where people were sneezing, coughing and talking, they got it from others who were admitted in the crowded hospitals. Mortality due to post-operative infections was very high.

In the 1840s, operative surgery was a filthy business fraught with hidden dangers. It was to be avoided at all costs. Due to the risks, many surgeons refused to operate altogether, choosing instead to limit their scope to the treatment of external ailments like skin conditions and superficial wounds. ... The surgeon, wearing a blood-encrusted apron, rarely washed his hands or his instruments and carried with him into the theatre the unmistakable smell of rotting flesh, which those in the profession cheerfully referred to as “good old hospital stink.” ...At a time when surgeons believed pus was a natural part of the healing process rather than a sinister sign of sepsis, most deaths were due to postoperative infections. Operating theatres were gateways to death. It was safer to have an operation at home than in a hospital, where mortality rates were three to five times higher than they were in domestic settings.

The book starts with discovery of anaesthesia and then quickly moves to its main subject - the ideas of antisepsis and their impact. It tells the story of Joseph Lister and his ideas about prevention of infections during surgery. During 1850s, Louis Pasteur in Paris had come up with the theory of invisible germs which were responsible for souring milk and fermenting grape-juice for making wine. In 1862 he boiled milk, which prevented souring of milk and proved his theory. Lister, who was passionate about microscopes, heard about Pasteur's work and felt that similar microscopic germs were responsible for causing infections in patients during surgery. In 1865 he developed his antiseptic solution based on carbolic acid, and showed that it was possible to reduce the post-operative mortality due to infections.

The book starts with discovery of anaesthesia and then quickly moves to its main subject - the ideas  of antisepsis and their impact. It tells the story of Joseph Lister and his ideas about prevention of infections during surgery. During 1850s, Louis Pasteur in Paris had come up with the theory of invisible germs which were responsible for souring milk and fermenting grape-juice for making wine. In 1862 he boiled milk, which prevented souring of milk and proved his theory. Lister, who was passionate about microscopes, heard about Pasteur's work and felt that similar microscopic germs were responsible for causing infections in patients during surgery. In 1865 he developed his antiseptic solution based on carbolic acid, and showed that it was possible to reduce the post-operative mortality due to infections.

The book is a fascinating read. Even if Lister proved the importance of antisepsis in preventing infections, for a long time, surgeons were sceptical about his ideas. Lister was helped by others who helped in spreading his ideas. He had inspired the maker of Listerine , which is now known as a mouth-wash but was initially developed as a disinfectant in operation theatres and used for cleaning wounds. He had also inspired Robert Wood Johnson , who had started Johnson & Johnson company to make sterilised dressings and sutures. It was not until 1877, when Armour Hansen saw the leprosy bacillus under a microscope, identified it as the cause of leprosy and firmly established the germs theory of infections.

Surgery in Ancient India

Sushruta is considered as the father of shalya-chikitsa (surgery) in Ayurveda. Various modern text books on surgery and plastic- surgery acknowledge that some of the techniques described in his treatise "Sushruta Samhita", such as that of full-thickness skin graft and rhinoplasty, have inspired them and are still used. When I read the Fitzharris' book, I wondered how did the ancient Indians develop those surgical skills without modern anaesthesia and antisepsis? To make a full-thickness skin graft or to do rhinoplasty, the surgeons need patients who are calm and can lie still for some time. It was not a work that a person with brute force could do by cutting away a part of the body while others held the patient. Such delicate surgeries would have been wasted if there were post-operative infections. So how did ancient Indian surgeons such as Sushruta do those surgeries?

I searched on internet and found an English translation of the first volume of Sushruta Samhita - it was translated from Sanskrit by an Ayurvedic doctor called Kaviraj Kunjalal Bhishagratna in 1907. In the introduction to the volume, he explained that this was not the original text of Samhita written by Sushruta, rather it was a commented version written by a person called Nagarjuna and was probably written around 3rd or 4th century BCE.

I found some answers regarding the questions of anaesthesia and use of anti-sepsis in surgery in the introduction of this text:

Verses about medicine, hygiene and surgery lie scattered through out the four Vedas. ... There were 5 groups [of healers] - Rogaharas (physicians), Shalyaharas (surgeons), Vishaharas (poison curers), Krityaharas (demon doctors) and Bhisag-Atharvans (magic doctors). (p. 13)[Sushruta] first classified all surgical operations into different kinds ... Aharya (extraction of solid bodies), Bhedya (excising), Chhedya (incising), Eshya (probing), Sivya (suturing), Vedhya (punturing), and Visravanya (evacuating liquids). ... Sushruta enjoins the sick room to be fumigated with the vapours of white mustard, bdellium, nimva leaves and resinous gums of Shala trees, which foreshadows the antiseptic (bacilli) theory of modern times. (p. 16)Amputations were freely made and medicated wines were given to patients as anaesthetics. ... In those old days, perhaps there were no hospitals to huddle patients together in the same room and thereby to create artificially septicemic poisons which are now so common and so fatal in the lying-in rooms. A newly built lying-in room in an open space filled with the rays of the sun and the heat of burning fire, and for each individual case the recommendation of a fresh bamboo chip for the section of the [umblical] cord are suggestions the value of which, the west has yet to learn from the east. (p. 19-20)

This brief description shows that in many ways, Ayurvedic surgeons had found solutions to the problems of sepsis and anaesthesia, which had plagued the surgeons in the UK till 19th century. Use of fumigation, sun light, keeping persons separated, using a new and clean cutting instrument, are all ideas that are known to promote antisepsis. Use of medicated wines for anaesthesia needs to be understood better to see which kind of medications were used. My knowledge of Sanskrit is limited but probably there would be more detailed information in the texts of Sushruta Samhita, which can give us more precise answers.

Those understandings of ancient healers like Sushruta were probably based on centuries of observations and experiments, though they had no real understanding of different kinds of bacteria and infectious agents as there were no microscopes to directly observe the micro-organisms. As the quote about different kinds of healers shows, the world of ancient healers was also a world of magic and demons, and thus it is likely that many of the old ideas would be expressed in "unscientific" terms.

Challenges of Understanding Ancient Wisdom

I think that at least some of such ancient understandings were common heritage of humanity and not just limited to India. In large parts of the world such ancient knowledge has been lost because many of the old traditions, along with old gods and their myths were discarded, before they could be codified, written down and preserved for posterity. It is easy to discredit ancient experiential knowledge because it is expressed in unscientific terms and is associated with old myths and ideas of supernatural. In India, in spite of invasions and mixing of cultures, fortunately there has been a civilisational continuity and thus the traditional knowledge in the old texts has been kept alive, and even today Ayurveda is a living tradition, followed by millions of persons.

Unfortunately, there is a tendency in India to diminish the importance of Ayurveda and its knowledge, as explained so eloquently in a recent article by Madhulika Banerjee, where she has written:

... my research has shown me several other worlds of Ayurveda — the world of the practising Ayurvedic doctor, the teachers in the scores of colleges and universities of Ayurveda and researchers in different institutes. These worlds are much bigger and deeper, beyond that of Patanjali, Dabur and Himalaya. That world is vibrant, has integrity and it is important that it be known, respected and valued. ... Under the influence of colonialism, we tethered the language, the institutions and the systems of Ayurvedic knowledge production to the margins of our learning and education. We closed many doors and windows of scientific practices within and around traditional medical systems. But in a trick of inversion, we say they do not follow the language and methodology of science.Despite Ayurvedic knowledge being rooted in a different philosophy, teachers have found ways of keeping up the process of adapting learning from the texts to contemporary education, fitting into modern classifications of anatomy, physiology and higher specialisations at a deeper level. They have both adapted to and adopted new knowledge, widening their horizons unhesitatingly, true to their tradition. Yet they have to face unhappy students, struggling with low self-esteem, under immense pressure to compromise their knowledge.... When two knowledge traditions have two completely different perspectives on body and disease, then why compete on the medicine and cure? And when parameters of treatment and expected outcomes are of different kinds, then how can the protocols of biomedicine be used for evaluating Ayurvedic medicines? Why can Ayurvedic manufacturing not focus on creating a different world of diagnosis, treatment and cure in keeping with its perspective, expanding the range of choices patients have?
I feel that the last part of Banerjee's quote above is fundamental - the value of the knowledge in Ayurveda can not be and should not be limited to evaluations by "scientists", it also needs to be understood and judged according to its own perspectives. For example, words like dosha, pitta, kapha and vayu, which are fundamental to ideas of Ayurveda, represent complex ideas that can not be translated into illness, bile, mucous and air and then laughed at, because they do not fit our understandings as modern doctors.

As explained in my blog-post on Ganesha story and ancient Ayurvedic techniques of plastic surgery operations on the nose (rhinoplasty), these were copied by British surgeons from India fairly recently (during the last part of 18th century). Yet, that does not stop "modern" doctors from calling Ayurveda as "alternative" medicine or worse, implying that these are inferior knowledge systems, if not outright quackery.

Conclusions

Linda Fitzharris' book on the old surgical art of butchering provides a glimpse into that time when getting a tooth extraction or having an abscess incised could lead to sepsis and death. It was also a time of unimaginable pain as persons were immobilised while the surgeons amputated their limbs or did similar operations. Discovery of anaesthetics and an understanding of spread of infections has led to the world today, where we have advances like laproscopic surgery, laser surgery and robots which can do delicate operations.

Forty years ago, when I had studied medicine, I had learned how to use ether anaesthesia for work in rural hospitals which did not have access to a Boyle's machine for anaesthesia. It was still the same technology which Fitzharris has described in her book as taking place in 1846. I don't know if anywhere anyone still uses that primitive approach to anaesthesia! So in way, I could directly identify with that world and feel the horrors of having brutal surgeries without anaesthesia.

It was also enlightening to read the book about Sushruta's techniques of surgery more than 2,500 years ago and appreciate how he and other ancient healers in India had developed an understanding about both anaesthesia and asepsis and were able to conduct and develop complex surgical techniques and to find that some of these techniques were copied in the west fairly recently (in 18th century).

I don't think that Ayurveda and ancient texts like Sushruta Samhita would all make sense according to the modern scientific understandings. They are texts of their times and they would have their parts of myths, stories and fantasies, interspersed with real experiential knowledge. As my brief exposition above shows, they did develop understandings which the modern medicine has developed only relatively recently. They do merit respectful analysis, even when we can't understand their meanings.

End-Note: The images used with this post are from the old anatomy theatre of Bologna in Italy and from an Ayurvedic college in Kerala, India.

*****

#bookreview #surgery #historyofsurgery #ayurvedicsurgery #ayurveda #lindseyfitzharris